منابع مشابه
Biomarkers of Alzheimer disease.
A definitive diagnosis of Alzheimer disease (AD) depends on finding widespread neurofibrillary tangles and plentiful neuritic plaques in the brain of an individual with a clinical diagnosis of progressive dementia. Using contemporary diagnostic criteria, the antemortem diagnosis of probable AD in centers specialized for AD is confirmed 80% to 90% of the time. There is the suspicion, but no firm...
متن کاملFluid biomarkers in Alzheimer disease.
Research progress has provided detailed understanding of the molecular pathogenesis of Alzheimer disease (AD). This knowledge has been translated into new drug candidates with putative disease-modifying effects, which are now being tested in clinical trials. The promise of effective therapy has created a great need for biomarkers able to detect AD in the predementia phase, because drugs will pr...
متن کاملThe most valuable biomarkers of Alzheimer\'s disease: a review article
Alzheimer’s disease (AD) is the most popular type of dementia in elderly and is described by a progressive loss of cognitive capacity and severe neurodegeneration which typically begins with memory deficits. The major biomarkers of AD include total tau, phosphorylated-tau and 42 amino acid isoform of amyloid beta that reflect neurodegeneration and indicate the pathophysiological processes in AD...
متن کاملProteomic Biomarkers in Alzheimer s disease
Alzheimer’s disease (AD) is a major problem of health in developed countries. From a pathogenic perspective, this prevalent form of dementia is a polygenic/complex disorder in which over 600 defective genes distributed across the human genome may be involved, in conjunction with epigenetic aberrations and diverse environmental risk factors [1]. The abnormal expression of genes and subsequent po...
متن کاملBiomarkers, assays, and therapies for Alzheimer disease.
The initial pathophysiologic changes of AD are found in the hippocampus region of the brain, disrupting memory and the ability to learn. AD progression is linked to nerve cell dysfunction and cell death due to the accumulation of 2 protein aggregates: -amyloid (A ) and tau. In the cerebrospinal fluid (CSF), these proteins are biomarkers for AD. Cleavage of the amyloid precursor protein (APP) ge...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 1999
ISSN: 0003-9942
DOI: 10.1001/archneur.56.3.281